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TRPC3 Antibody - N-terminal region : HRP (ARP58715_P050-HRP)

Selected Variant

ARP58715_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Transient receptor potential cation channel, subfamily C, member 3

Gene Aliases

TRP3, SCA41

Gene ID

7222

Swiss Prot

Q13507

Accession Number

NP_003296

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the n terminal region of human TRPC3

Target

TRPC3 is thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. TRPC3 is activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5-triphosphate receptors (ITPR) with bound IP3. TRPC3 may also be activated by internal calcium store depletion.

Partner Proteins

STX3; TRPC1; PRKG1; ORAI1; PLCB1; PLCB2; TRPC6; NAPA; PLCB3; FKBP1A; VAMP2; SLC8A1; PRKCA; PLCG1; ITPR3; ITPR1; MX1; GNA11; CALM1; TRPC7; TRPC3; TRPC5; TRPC4

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB, IHC

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

97kDa

References & Citations

Lof, C., (2008) J. Cell. Physiol. 216 (1), 245-252

Shipping Conditions

Wet Ice

Protein Length

848

NCBI Gene Symbol

TRPC3

NCBI GB Accession Number

TRPC3

Host or Source

Rabbit

Protein Name

Short transient receptor potential channel 3

Nucleotide Accession Number

NM_003305

Peptide Sequence

MEGSPSLRRMTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYG

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