UBA1 Antibody - N-terminal region : Biotin (ARP58687_P050-Biotin)
Product Specifications
Gene Name
Ubiquitin-like modifier activating enzyme 1
Gene Aliases
A1S9, A1ST, GXP1, UBE1, A1S9T, AMCX1, POC20, SMAX2, UBA1A, UBE1X, VEXAS, CFAP124
Gene ID
7317
Swiss Prot
P22314
Accession Number
NP_003325
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human UBA1
Target
UBA1 activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described.
Partner Proteins
USP5; UBE2D2; UBC; FUS; ISG15; UBTD2; HUWE1; UBE2L3; UBE2D1; SUMO2; CDC34; UBE2K; UBE2W; UBE2R2; UBE2J1; UBE2T; UBE2S; UBE2C; UBE2E3; UBE2H; UBE2G2; UBE2G1; UBE2E2; UBE2E1; UBE2D3; UBE2B; UBE2A; UBI4; MDM2; TRIM25; XPNPEP1; EZR; MC1R; IPO5; FH; CTPS1; ATI
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
116kDa
References & Citations
Ramser, J., (2008) Am. J. Hum. Genet. 82 (1), 188-193
Shipping Conditions
Wet Ice
Protein Length
1058
NCBI Gene Symbol
UBA1
NCBI GB Accession Number
UBA1
Host or Source
Rabbit
Protein Name
Ubiquitin-like modifier-activating enzyme 1
Nucleotide Accession Number
NM_003334
Peptide Sequence
MEAGPPGSARPAEPGPCLSGQRGADHTASASLQSVAGTEPGRHPQAVAAV
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