MVP Antibody - N-terminal region : Biotin (ARP58642_P050-Biotin)

MVP is required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. MVP down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. MVP down-regulates SRC activity and signaling through MAP kinases.This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.

MVP; SKIL; TRIM27; REL; PLSCR1; MEOX2; MEOX1; MDFI; KPNA3; GOLGA2; DLX2; CAMK2B; AES; TRIP6; TRAF2; TP53; TFCP2; TCF4; SUMO2; NOTCH2NL; CCDC36; TRIM42; FAM154A; PIH1D2; RAB3IP; RIMBP3; C1orf94; RHOXF2; ZMIZ2; OBFC1; RFWD2; MKL1; VAC14; BANP; FAM46C; KCTD9

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.