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FN3KRP Antibody - N-terminal region : Biotin (ARP58624_P050-Biotin)

Selected Variant

ARP58624_P050-Biotin

Size: 100 µL

Product Specifications

Gene Name

Fructosamine 3 kinase related protein

Gene Aliases

FN3KL

Gene ID

79672

Swiss Prot

Q9HA64

Accession Number

NP_078895

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human FN3KRP

Target

FN3KRP phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein-bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation.FN3KRP and FN3K (MIM 608425) protect proteins from nonenzymatic glycation by phosphorylating the modified amino acid. This phosphorylation destabilizes the sugar-amine linkage and leads to spontaneous decomposition (Conner et al., 2004 [PubMed 15381090]) .[supplied by OMIM].

Partner Proteins

APP; CUL3; CUL4B; UBC; USP43

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

FN3KRP is supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Cow: 86%; Dog: 86%; Guinea Pig: 86%; Horse: 86%; Human: 100%; Mouse: 86%; Rabbit: 86%; Rat: 93%; Zebrafish: 79%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

34kDa

References & Citations

Szwergold, B., (2007) Biochem. Biophys. Res. Commun. 361 (4), 870-875

Shipping Conditions

Wet Ice

Protein Length

309

NCBI Gene Symbol

FN3KRP

NCBI GB Accession Number

FN3KRP

Host or Source

Rabbit

Protein Name

Ketosamine-3-kinase

Nucleotide Accession Number

NM_024619

Peptide Sequence

MDPGDPAGDPAAGERHRMGRDPLLLLQALQTLWSTRERKQLREEAWRGFA

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