PPP4C Antibody - middle region : FITC (ARP58516_P050-FITC)

Product Specifications

Gene Name

Protein phosphatase 4, catalytic subunit

Gene Aliases

PP4, PPX, PP-X, PP4C, PPH3, PPP4

Gene ID

5531

Swiss Prot

P60510

Accession Number

NP_002711

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human PPP4C

Target

PPP4C is a protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF) -alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDC2/Cdk1 phosphorylation sites and negatively regulates CDC2/Cdk1 activity in interphase.

Partner Proteins

SUMO2; IKBKG; MAP4K1; BAG6; TCP1; UBC; CAND1; CUL3; Igbp1; TRIM28; ELAVL1; TK1; PPP2R5D; PPP2R4; PPP2R2B; PPP2R1A; EEF1A1; CCT6A; SMEK2; PPP2R2D; SMEK1; ATAD3A; PPME1; CCT5; CCT8; CCT2; CCT4; CCT7; PPP4R1; PLOD3; CCDC6; TUBA3C; CCT3; CCT6P1; GLYATL3; PPP4

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 79%; Zebrafish: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.