PNPO Antibody - N-terminal region : Biotin (ARP58515_P050-Biotin)
Product Specifications
Gene Name
Pyridoxamine 5'-phosphate oxidase
Gene Aliases
PDXPO, HEL-S-302
Gene ID
55163
Swiss Prot
Q9NVS9
Accession Number
NP_060599
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human PNPO
Target
PNPO catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine.Vitamin B6, or pyridoxal 5-prime-phosphate (PLP), is critical for normal cellular function, and some cancer cells have notable differences in vitamin B6 metabolism compared to their normal counterparts. The rate-limiting enzyme in vitamin B6 synthesis is pyridoxine-5-prime-phosphate (PNP) oxidase (PNPO; EC 1.4.3.5) .[supplied by OMIM].
Partner Proteins
UBC; LPP; APP; ELAVL1
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 86%; Dog: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
29kDa
References & Citations
Song, H., Schizophr. Res. 97 (1-3), 264-270 (2007)
Shipping Conditions
Wet Ice
Protein Length
261
NCBI Gene Symbol
PNPO
NCBI GB Accession Number
PNPO
Host or Source
Rabbit
Protein Name
Pyridoxine-5'-phosphate oxidase
Nucleotide Accession Number
NM_018129
Peptide Sequence
PMRKSYRGDREAFEETHLTSLDPVKQFAAWFEEAVQCPDIGEANAMCLAT
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