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G6PD Antibody - middle region : Biotin (ARP58469_P050-Biotin)

Product Specifications

Gene Name

Glucose-6-phosphate dehydrogenase

Gene Aliases

G6PD1

Gene ID

2539

Swiss Prot

P11413

Accession Number

NP_000393

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human G6PD

Target

G6PD is a glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene.

Partner Proteins

G6PD; SUMO2; UBC; MDM2; CKB; CAPN1; ALDH7A1; ZNF622; ZFYVE19; UBFD1; CNDP2; ISOC1; MAT2B; ERP44; YWHAQ; SLC9A3R1; YWHAZ; YWHAH; YWHAG; YWHAE; YWHAB; EIF4H; VCL; UBE2V1; TGM2; PPP1R2; PGD; PAK2; LDHB; SFN; GNS; GLA; GBP2; EIF5; BAG3; FN1; CCT4; HARS; SUMO4

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

G6PD is supported by BioGPS gene expression data to be expressed in MCF7

Concentration

0.5 mg/ml

Homology

Cow: 85%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 86%; Rabbit: 93%; Rat: 86%; Sheep: 83%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

57kDa

References & Citations

Langbein, S., (2008) Int. J. Cancer 122 (11), 2422-2428

Shipping Conditions

Wet Ice

Protein Length

515

NCBI Gene Symbol

G6PD

NCBI GB Accession Number

G6PD

Host or Source

Rabbit

Protein Name

Glucose-6-phosphate 1-dehydrogenase

Nucleotide Accession Number

NM_000402

Peptide Sequence

VTKNIHESCMSQIGWNRIIVEKPFGRDLQSSDRLSNHISSLFREDQIYRI

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