USP22 Antibody - middle region : Biotin (ARP58353_P050-Biotin)

Product Specifications

Gene Name

Ubiquitin specific peptidase 22

Gene Aliases

USP3L

Gene ID

23326

Swiss Prot

Q9UPT9

Accession Number

NP_056091

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human USP22

Target

USP22 is a subunit of the SAGA transcriptional cofactor complex. It deubiquitylates histone H2B and is recruited to specific genes by activators like Myc. USP22 is needed for cell cycle progression. It deubiquitylates histone H2A in addition to H2B. Altered mRNA expression is associated with therapy failure and death in patients multiple types of cancer.

Partner Proteins

UBC; AASDHPPT; STAT3; TAF10; TADA2A; ATXN7; MYC; KAT2A; TRRAP; TAF9B; HIST1H2BD; TADA3; SUMO1; NFATC2; SIRT1; ATXN7L3; FUBP1; HIST2H2BE; HIST2H2AC; MRPL44; ATXN7L3B; USP27X; KIF7; KLHL23; ATXN7L2; TADA1; CCDC101; TADA2B; ENY2; SUPT20H; TAF5L; SND1; CNOT10

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.