USP22 Antibody - N-terminal region : FITC (ARP58352_P050-FITC)
Selected Variant
ARP58352_P050-FITC
Size: 100 µL
Product Specifications
Gene Name
Ubiquitin specific peptidase 22
Gene Aliases
USP3L
Gene ID
23326
Swiss Prot
Q9UPT9
Accession Number
NP_056091
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human USP22
Target
USP22 is a subunit of the SAGA transcriptional cofactor complex. It deubiquitylates histone H2B and is recruited to specific genes by activators like Myc. USP22 is needed for cell cycle progression. It deubiquitylates histone H2A in addition to H2B. Altered mRNA expression is associated with therapy failure and death in patients multiple types of cancer.
Partner Proteins
UBC; AASDHPPT; STAT3; TAF10; TADA2A; ATXN7; MYC; KAT2A; TRRAP; TAF9B; HIST1H2BD; TADA3; SUMO1; NFATC2; SIRT1; ATXN7L3; FUBP1; HIST2H2BE; HIST2H2AC; MRPL44; ATXN7L3B; USP27X; KIF7; KLHL23; ATXN7L2; TADA1; CCDC101; TADA2B; ENY2; SUPT20H; TAF5L; SND1; CNOT10
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 86%; Dog: 86%; Guinea Pig: 100%; Horse: 79%; Human: 100%; Mouse: 86%; Rabbit: 93%; Rat: 100%; Zebrafish: 93%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
60kDa
References & Citations
Zhang, X.Y., (2008) Mol. Cell 29 (1), 102-111
Shipping Conditions
Wet Ice
Protein Length
525
NCBI Gene Symbol
USP22
NCBI GB Accession Number
USP22
Host or Source
Rabbit
Protein Name
Ubiquitin carboxyl-terminal hydrolase 22
Nucleotide Accession Number
NM_015276
Peptide Sequence
RLHSCLYCVFFGCFTKKHIHEHAKAKRHNLAIDLMYGGIYCFLCQDYIYD
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