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TNKS1BP1 Antibody - middle region : HRP (ARP58347_P050-HRP)

Selected Variant

ARP58347_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Tankyrase 1 binding protein 1, 182kDa

Gene Aliases

TAB182

Gene ID

85456

Swiss Prot

Q9C0C2

Accession Number

NP_203754

Host

Rabbit

Reactivity

Human

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human TNKS1BP1

Target

TNKS-1 mRNA in urine sediment from patients with bladder TCC correlated with tumor stage, and higher preoperative levels were associated with increased risk of early recurrence. Tankyrase-1 is required in the assembly of bipolar spindles and the spindle-pole protein NuMA as a substrate for covalent modification by tankyrase-1. Data also show that tankyrase 1 inhibition in human cancer cells enhances telomere shortening by a telomerase inhibitor and hastens cell death.

Partner Proteins

UBC; RNF219; SPC25; RABGEF1; DCTN3; SPTBN1; NLK; CSNK2A1; CNOT6L; CNOT6; VCP; HNRNPK; DYNC1H1; CBX3; SIRT7; TSG101; Cnot3; Capza1; TNKS2; TNKS

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Human: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

190kDa

References & Citations

Gelmini, S., (2007) Clin. Chem. Lab. Med. 45 (7), 862-866

Shipping Conditions

Wet Ice

Protein Length

1729

NCBI Gene Symbol

TNKS1BP1

NCBI GB Accession Number

TNKS1BP1

Host or Source

Rabbit

Protein Name

182 kDa tankyrase-1-binding protein

Nucleotide Accession Number

NM_033396

Peptide Sequence

DGEASQTEDVDGTWGSSAARWSDQGPAQTSRRPSQGPPARSPSQDFSFIE

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