TNKS1BP1 Antibody - middle region : Biotin (ARP58347_P050-Biotin)
Selected Variant
ARP58347_P050-Biotin
Size: 100 µL
Product Specifications
Gene Name
Tankyrase 1 binding protein 1, 182kDa
Gene Aliases
TAB182
Gene ID
85456
Swiss Prot
Q9C0C2
Accession Number
NP_203754
Host
Rabbit
Reactivity
Human
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human TNKS1BP1
Target
TNKS-1 mRNA in urine sediment from patients with bladder TCC correlated with tumor stage, and higher preoperative levels were associated with increased risk of early recurrence. Tankyrase-1 is required in the assembly of bipolar spindles and the spindle-pole protein NuMA as a substrate for covalent modification by tankyrase-1. Data also show that tankyrase 1 inhibition in human cancer cells enhances telomere shortening by a telomerase inhibitor and hastens cell death.
Partner Proteins
UBC; RNF219; SPC25; RABGEF1; DCTN3; SPTBN1; NLK; CSNK2A1; CNOT6L; CNOT6; VCP; HNRNPK; DYNC1H1; CBX3; SIRT7; TSG101; Cnot3; Capza1; TNKS2; TNKS
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Human: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
190kDa
References & Citations
Gelmini, S., (2007) Clin. Chem. Lab. Med. 45 (7), 862-866
Shipping Conditions
Wet Ice
Protein Length
1729
NCBI Gene Symbol
TNKS1BP1
NCBI GB Accession Number
TNKS1BP1
Host or Source
Rabbit
Protein Name
182 kDa tankyrase-1-binding protein
Nucleotide Accession Number
NM_033396
Peptide Sequence
DGEASQTEDVDGTWGSSAARWSDQGPAQTSRRPSQGPPARSPSQDFSFIE
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