RB1 Antibody - N-terminal region : FITC (ARP58065_P050-FITC)
Selected Variant
ARP58065_P050-FITC
Size: 100 µL
Product Specifications
Gene Name
Retinoblastoma 1
Gene Aliases
RB, pRb, OSRC, pp110, p105-Rb, PPP1R130, p110-RB1
Gene ID
5925
Swiss Prot
P06400
Accession Number
NP_000312
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Pig, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human RB1
Target
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Partner Proteins
RAF1; E2F1; ABL1; HDAC1; KDM2A; SMARCA4; USP7; UBC; DYRK1A; NEFM; DYRK1B; MAGEA11; ENC1; PPP1CA; CDKN1C; CDKN1A; CDK6; CDK4; CDK2; CCNE1; CCNA2; CCND1; HDAC11; PAX5; HIF1A; E2F4; CEBPE; CCNA1; SUMO1; UBE2I; TFAP2A; CDK3; CDK1; CCNC; CCNB1; MRPS18B; SUMO2
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Sample Type
RB1 is strongly supported by BioGPS gene expression data to be expressed in Jurkat
Concentration
0.5 mg/ml
Homology
Cow: 93%; Human: 100%; Mouse: 80%; Pig: 93%; Rabbit: 93%; Rat: 79%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
106kDa
Shipping Conditions
Wet Ice
Protein Length
928
NCBI Gene Symbol
RB1
NCBI GB Accession Number
RB1
Host or Source
Rabbit
Protein Name
Retinoblastoma-associated protein
Nucleotide Accession Number
NM_000321
Peptide Sequence
MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFE
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