APEX1 Antibody - N-terminal region : HRP (ARP58027_P050-HRP)
Selected Variant
ARP58027_P050-HRP
Size: 100 µL
Product Specifications
Gene Name
APEX nuclease (multifunctional DNA repair enzyme) 1
Gene Aliases
APE, APX, APE1, APEN, APEX, HAP1, REF1
Gene ID
328
Swiss Prot
P27695
Accession Number
NP_001632
Host
Rabbit
Reactivity
Human, Pig
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human APEX1
Target
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.
Partner Proteins
GADD45A; UBC; RPA3; RPA2; RPA1; rev; CCDC124; RIC8A; PABPC1; TWF2; XPOT; HNRNPUL1; ARIH2; PAPSS2; NAE1; PSMG1; TXNRD1; TXN; TCEB1; LGALS1; HNRNPK; CAPNS1; SRPK2; SRPK1; MUTYH; HMGA1; HMGA2; GZMK; GZMA; YBX1; EP300; ASCL2; STAT3; SNRPD1; SFPQ; APP; UBE2I
Clonality
Polyclonal
Conjugation
HRP: Horseradish Peroxidase
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Sample Type
APEX1 is supported by BioGPS gene expression data to be expressed in MCF7
Concentration
0.5 mg/ml
Homology
Human: 100%; Pig: 79%
Format
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
35kDa
Shipping Conditions
Wet Ice
Protein Length
318
NCBI Gene Symbol
APEX1
NCBI GB Accession Number
APEX1
Host or Source
Rabbit
Protein Name
DNA- (apurinic or apyrimidinic site) lyase
Nucleotide Accession Number
NM_001641
Peptide Sequence
MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPD
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