ERCC8 Antibody - middle region : FITC (ARP57956_P050-FITC)
Product Specifications
Gene Name
Excision repair cross-complementing rodent repair deficiency, complementation group 8
Gene Aliases
CSA, CKN1, UVSS2
Gene ID
1161
Swiss Prot
Q13216
Accession Number
NP_000073
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human ERCC8
Target
ERCC8 is a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS) .This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS) . CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
Partner Proteins
CUL4A; CUL4B; DDB1; RUVBL2; ZNF24; PCNA; H1F0; ERCC6; UVSSA; DDA1; RFWD2; COPS4; COPS6; COPS3; TOP1; TP53; SSBP1; OGG1; MDM2; GTF2H2; CUL5; GPS1; DDB2; COPS2; COPS7A; COPS5; COPS8; RBX1; POLR2A; HMGN1; EP300; UBC; CSNK2B; XAB2; UQCRQ; CBR1
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 93%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 93%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
44kDa
References & Citations
Bethke, L., (2008) J. Natl. Cancer Inst. 100 (4), 270-276
Shipping Conditions
Wet Ice
Protein Length
396
NCBI Gene Symbol
ERCC8
NCBI GB Accession Number
ERCC8
Host or Source
Rabbit
Protein Name
DNA excision repair protein ERCC-8
Nucleotide Accession Number
NM_000082
Peptide Sequence
VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGT
Frequently Asked Questions
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