PSMD12 Antibody - middle region : Biotin (ARP57840_P050-Biotin)

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3.

FUS; HUWE1; SUMO2; UBC; PSMD14; RNF2; KIAA0368; HNRNPA0; TXNL1; SQSTM1; PSMD11; PSMD3; PSMD1; PSMC6; PSMC5; PSMC4; PSMC2; PSMC1; FLNC; FLNB; KCMF1; PARK2; BAG3; RNF11; NPM1; NOS2; PSMD6; PSMD13; PSMD7; UGGT1; PSME3; USP14; PSME1; PSMD10; PSMD8; PSMD4; PSM

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.