PKM2 Antibody - middle region : Biotin (ARP57789_P050-Biotin)
Product Specifications
Gene Name
Pyruvate kinase, muscle
Gene Aliases
PK3, TCB, p58, OIP3, PKM2, CTHBP, THBP1, HEL-S-30
Gene ID
5315
Swiss Prot
P11980
Accession Number
NP_002645
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Yeast, Zebrafish
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human PKM2
Target
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.
Partner Proteins
LNX1; NXT2; HUWE1; ISG15; UBC; POLE2; FUS; SUMO2; SUMO3; STAU1; MDM2; SUZ12; EZH2; IPO11; TWF2; PDLIM5; NPLOC4; PLIN3; UBA2; EIF4A3; ANP32A; SRP14; RAD23B; PPP1CA; PIN1; CTPS1; CBS; CAPZA2; ACAT2; NLK; FBXO6; YWHAQ; RAF1; IGSF8; HDAC6; MAPK7; NPM1; CDK2
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Sample Type
PKM is supported by BioGPS gene expression data to be expressed in HeLa
Concentration
0.5 mg/ml
Homology
Cow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Sheep: 77%; Yeast: 85%; Zebrafish: 93%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
58kDa
Shipping Conditions
Wet Ice
Protein Length
531
NCBI Gene Symbol
PKM
NCBI GB Accession Number
PKM
Host or Source
Rabbit
Protein Name
Pyruvate kinase isozymes M1/M2
Nucleotide Accession Number
NM_002654
Peptide Sequence
HLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQ
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