ML311
ML311 is a potent and selective inhibitor of the Mcl-1/Bim interaction.
Product Specifications
CAS Number
[315698-17-0]
Product Name Alternative
EU-5346
UNSPSC
12352005
Hazard Statement
H302, H315, H318, H335
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ML311.html
Purity
98.98
Solubility
DMSO : 67.5 mg/mL (ultrasonic)
Smiles
OC1=C2N=CC=CC2=CC=C1C(N3CCN(CC)CC3)C4=CC=C(C(F)(F)F)C=C4
Molecular Formula
C23H24F3N3O
Molecular Weight
415.45
Precautions
H302, H315, H318, H335
References & Citations
[1]Bannister T, et al. ML311: A Small Molecule that Potently and Selectively Disrupts the Protein-Protein Interaction of Mcl-1 and Bim: A Probe for Studying Lymphoid Tumorigenesis. Biotechnology Information (US) ; 2010-2012 Apr 16.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bim; Mcl-1
Available Sizes
Curated Selection
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