PLAT Antibody - middle region : Biotin (ARP57691_P050-Biotin)

This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

PDGFC; POT1; TERF2; CKAP4; LRP1B; GRIN1; SERPING1; SERPINI1; SERPINA5; MAPK3; LAMA3; F10; PLAU; CLEC3B; SPARC; MAPK1; PLAT; SERPINE1; PLG; HMGB1; ANXA2; LAMA1; KRT8; FGA; CALR; LRP1; FN1; LAMA5; F2

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.