MRE11 Antibody - N-terminal region : Biotin (ARP56644_P050-Biotin)

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

HUWE1; CIAO1; ATRX; BRCA1; RPA3; RPA2; RPA1; EED; ABCF1; C14orf166; RTCB; RPL26L1; NELFB; IGF2BP3; LRRFIP1; MAP7; EIF2B2; EIF2B3; YBX3; RPL27; RFC4; QARS; NMT1; HNRNPM; ILF2; HNRNPU; HNRNPA2B1; FLII; DHX9; DDX1; LMNA; PAN2; UBC; MCM2; GINS1; MDC1; RNF8; C

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.