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NDUFS1 Antibody - middle region : HRP (ARP56609_P050-HRP)

Product Specifications

Gene Name

NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)

Gene Aliases

CI-75k, MC1DN5, CI-75Kd, PRO1304

Gene ID

4719

Swiss Prot

P28331

Accession Number

NP_004997

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human NDUFS1

Target

The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency.

Partner Proteins

SUMO2; HSFY1; UBC; MDM2; RNF2; KDM1A; FBXO6; VCAM1; BTK; Htt; NDUFS7; RHOT2; NDUFA12; TMEM126B; MRPL13; STX12; SEC24C; SDHB; RPL27; RAB5B; OPA1; NDUFV3; NDUFV2; NDUFS8; NDUFV1; NDUFS2; NDUFB10; NDUFB9; NDUFB5; NDUFA9; CPT1A; ATP5C1; ATP5B; CUL3; SIRT7; MY

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 93%; Goat: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

77kDa

Shipping Conditions

Wet Ice

Protein Length

727

NCBI Gene Symbol

NDUFS1

NCBI GB Accession Number

NDUFS1

Host or Source

Rabbit

Protein Name

NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Nucleotide Accession Number

NM_005006

Peptide Sequence

TPPGLAREDWKIIRALSEIAGMTLPYDTLDQVRNRLEEVSPNLVRYDDIE

Subunit

Mitochondrial

Frequently Asked Questions

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