SH3BP2 Antibody - middle region: Biotin (ARP56546_P050-Biotin)
Product Specifications
Gene Name
SH3-domain binding protein 2
Gene Aliases
3BP2, CRBM, CRPM, 3BP-2, RES4-23
Gene ID
6452
Swiss Prot
P78314
Accession Number
NP_003014
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human SH3BP2
Target
SH3BP2 has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases, and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism.
Partner Proteins
RNF146; TNKS2; PDLIM7; TNKS; UBC; ERBB2; VAV1; SYK; SRC; CBL; SH3KBP1; DBNL; VAV3; LAT; VAV2; PLCG2; TF; ABL1; ZAP70; PLCG1; LCK; YWHAQ; FYN; FLT3; FGFR1; GRB2
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
IHC, WB
Purification
Affinity Purified
Sample Type
SH3BP2 is strongly supported by BioGPS gene expression data to be expressed in 721_B
Concentration
0.5 mg/mL
Homology
Cow: 85%; Dog: 93%; Guinea Pig: 93%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
62kDa
Shipping Conditions
Wet Ice
Protein Length
561
NCBI Gene Symbol
SH3BP2
Protein Name
SH3 domain-binding protein 2
Nucleotide Accession Number
NM_003023
Curated Selection
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