SH3BP2 Antibody - middle region : Biotin (ARP56546_P050-Biotin)

Product Specifications

Gene Name

SH3-domain binding protein 2

Gene Aliases

3BP2, CRBM, CRPM, 3BP-2, RES4-23

Gene ID

6452

Swiss Prot

P78314

Accession Number

NP_003014

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human SH3BP2

Target

SH3BP2 has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases, and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism.

Partner Proteins

RNF146; TNKS2; PDLIM7; TNKS; UBC; ERBB2; VAV1; SYK; SRC; CBL; SH3KBP1; DBNL; VAV3; LAT; VAV2; PLCG2; TF; ABL1; ZAP70; PLCG1; LCK; YWHAQ; FYN; FLT3; FGFR1; GRB2

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Sample Type

SH3BP2 is strongly supported by BioGPS gene expression data to be expressed in 721_B

Concentration

0.5 mg/ml

Homology

Cow: 85%; Dog: 93%; Guinea Pig: 93%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.