PTPN11 Antibody - N-terminal region : FITC (ARP56493_P050-FITC)

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

TRIM32; RPIA; UBC; NEDD8; SUMO1; MTPN; EFHD2; CHRAC1; OXCT1; MAPK14; GRB2; Siglece; GAB2; GAB1; VCAM1; CD274; IQCB1; IRS1; ERBB2; EGFR; FASN; RFWD2; FRS2; PPIF; GSK3B; CRK; PIK3R2; PIK3R1; MAP3K5; LRRK1; CSF2RBP1; FYN; CBL; SOCS3; CXCR4; MYC; INPP5D; IL6S

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.