Psmd10 Antibody - N-terminal region : HRP (ARP56481_P050-HRP)
Product Specifications
Gene Name
Proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
Gene Aliases
Gan, AW554874
Gene ID
53380
Swiss Prot
Q9Z2X2
Accession Number
NP_058579
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Immunogen
The immunogen is a synthetic peptide corresponding to a region of Mouse
Target
Psmd10 acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC) . In the initial step of the base subcomplex assembly, Psmd10 is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module By similarity.Psmd10 acts as an oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression of this gene is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Psmd10 regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4.
Partner Proteins
Psmc4; Rb1; Cebpa; Cdk4
Clonality
Polyclonal
Conjugation
HRP: Horseradish Peroxidase
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%
Format
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
25kDa
Shipping Conditions
Wet Ice
Protein Length
231
NCBI Gene Symbol
PSMD10
NCBI GB Accession Number
Psmd10
Host or Source
Rabbit
Protein Name
26S proteasome non-ATPase regulatory subunit 10
Nucleotide Accession Number
NM_016883
Peptide Sequence
KERILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDA
Subunit
10
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