PSMD3 Antibody - middle region : Biotin (ARP56480_P050-Biotin)

Product Specifications

Gene Name

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 3

Gene Aliases

S3, P58, RPN3, TSTA2

Gene ID

5709

Swiss Prot

O43242

Accession Number

NP_002800

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human PSMD3

Target

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid.

Partner Proteins

CEP44; ZBTB43; HUWE1; SHFM1; SPRTN; SNAI2; STAU1; PSMD14; UBC; UBQLN1; FLNC; FLNB; PSMD8; PSMD4; PSMD1; PSMC6; PSMC5; PSMC4; PSMC3; PSMC2; PSMC1; KCMF1; UCHL5; KIAA0368; ADRM1; TXNL1; SQSTM1; RPS28; RPS21; RPS15A; RPS13; RPS8; PSMD12; PSMD11; PARK2; FBXO6

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 82%; Zebrafish: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.