PRKCI Antibody - middle region: FITC (ARP56427_P050-FITC)

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.

PARD6B; PARD6A; UBC; AMOT; SQSTM1; CRX; NPM1; IKBKG; YWHAE; IL1RAP; HSP90AA1; GAB1; CASP8; PARD3; APP; UBD; MAP2K5; MARK2; ARHGAP17; TJP1; ELAVL1; CDK7; MBP; TSC22D1; TTR; FABP4; PARD6G; MARK4; CDC37; RAPGEF2; PNMA1; NIPSNAP1; YWHAZ; YWHAH; MYO10; LLGL1

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.