PMS2 Antibody - middle region : Biotin (ARP56117_P050-Biotin)

Product Specifications

Gene Name

PMS2 postmeiotic segregation increased 2 (S. cerevisiae)

Gene Aliases

MLH4, PMSL2, HNPCC4, MMRCS4, PMS2CL

Gene ID

5395

Swiss Prot

P54278

Accession Number

NP_000526

Host

Rabbit

Reactivity

Human, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human PMS2

Target

PMS2 is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors.This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.

Partner Proteins

UBC; MLH1; PCNA; PMS2P1; NSF; MSH2; LMNA; MSH6; SPRTN; BRIP1; FAN1; CLSPN; TOPBP1; PSD2; MMS19; ATAD3A; NSUN2; UBR5; COPG2; PSD3; COPG1; RUVBL2; EXO1; AIFM1; RUVBL1; XPO1; SMARCA4; RFC2; PSMD5; PSMC6; PSMC3; PSMC2; PSMC1; PRKDC; PPP2CA; PIK3C2A; MSH3; MCM

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Sample Type

PMS2 is supported by BioGPS gene expression data to be expressed in HepG2

Concentration

0.5 mg/ml

Homology

Cow: 85%; Dog: 92%; Guinea Pig: 100%; Horse: 92%; Human: 100%; Rabbit: 92%; Rat: 92%; Yeast: 91%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.