MLH1 Antibody - N-terminal region : Biotin (ARP56076_P050-Biotin)

Product Specifications

Gene Name

MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)

Gene Aliases

FCC2, COCA2, HNPCC, hMLH1, HNPCC2, MMRCS1

Gene ID

4292

Swiss Prot

P40692

Accession Number

NP_000240

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human MLH1

Target

This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC) . It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC.This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC) . It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length natures have not been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Partner Proteins

SPERT; CXorf57; PSMA1; MYOG; MSH3; KPNA2; MLH3; ZC3H11A; EXO1; PMS2; MMS19; PCNA; DES; CTSB; ATF2; CKB; CAPN5; ASS1; TRIM23; ARAF; APRT; ANXA6; ANXA2; ALDOA; ACTG2; ACTG1; TXN2; GABARAP; EXOC3; CKAP4; AGR2; ZER1; NDRG1; AIFM1; SELENBP1; SQSTM1; FCGBP; ABC

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Sample Type

MLH1 is supported by BioGPS gene expression data to be expressed in HEK293T

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 83%; Zebrafish: 79%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.