PRAME Antibody - N-terminal region : Biotin (ARP55982_P050-Biotin)

PRAME functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. PRAME prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.

PRAME; RBX1; CUL2; TCEB2; TCEB1; ZNF408; FBXL12; XRN2; HIST4H4; HIST2H2BE; HIST2H2AC; HIST3H3; UBC; RARA; TP53RK; OSGEP; TPRKB; KDM1A; BAG2; LAGE3; UBL4A; SNRPB; RPS13; RPL22; RPL10; RFC4; PSMC4; HNRNPM; HNRNPH1; HNRNPF; HNRNPC; NEDD8; STK19

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.