TBC1D10C Antibody - N-terminal region : FITC (ARP55894_P050-FITC)
Product Specifications
Gene Name
TBC1 domain family, member 10C
Gene Aliases
EPI64C, CARABIN
Gene ID
374403
Swiss Prot
Q8IV04
Accession Number
NP_940919
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human TBC1D10C
Target
TBC1D10C inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. TBC1D10C acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.Carabin is an endogenous inhibitor of calcineurin (see MIM 114105) that also inhibits the Ras (see MIM 190020) signaling pathway through its intrinsic Ras GTPase-activating protein activity (Pan et al., 2007 [PubMed 17230191]) .[supplied by OMIM].
Partner Proteins
NOTCH2NL; KRTAP13-1; KLHL12; KRTAP5-9; HOXA1; APP; PPP3R2
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
50kDa
References & Citations
Pan, F., (2007) Nature 445 (7126), 433-436
Shipping Conditions
Wet Ice
Protein Length
446
NCBI Gene Symbol
TBC1D10C
NCBI GB Accession Number
TBC1D10C
Host or Source
Rabbit
Protein Name
Carabin
Nucleotide Accession Number
NM_198517
Peptide Sequence
MAQALGEDLVQPPELQDDSSSLGSDSELSGPGPYRQADRYGFIGGSSAEP
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