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TRIB2 Antibody - middle region : HRP (ARP55377_P050-HRP)

Selected Variant

ARP55377_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Tribbles homolog 2 (Drosophila)

Gene Aliases

C5FW, TRB2, GS3955

Gene ID

28951

Swiss Prot

Q92519

Accession Number

NP_067675

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human TRIB2

Target

TRIB2 is one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia.

Partner Proteins

RFWD2; SMURF1; BTRC; PRMT6; UBC; RPS6KB1; SLAMF7; APP; UBQLN4

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

39kDa

References & Citations

Lin, K.R., (2007) J. Biol. Chem. 282 (30), 21962-21972

Shipping Conditions

Wet Ice

Protein Length

343

NCBI Gene Symbol

TRIB2

NCBI GB Accession Number

TRIB2

Host or Source

Rabbit

Protein Name

Tribbles homolog 2

Nucleotide Accession Number

NM_021643

Peptide Sequence

YPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQE

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