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NKIRAS1 Antibody - N-terminal region : Biotin (ARP55370_P050-Biotin)

Selected Variant

ARP55370_P050-Biotin

Size: 100 µL

Product Specifications

Gene Name

NFKB inhibitor interacting Ras-like 1

Gene Aliases

KBRAS1, kappaB-Ras1

Gene ID

28512

Swiss Prot

Q9NYS0

Accession Number

NP_065078

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human NKIRAS1

Target

NKIRAS1 is an atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. NKIRAS1 may act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.

Partner Proteins

XRCC2; UBC; APP; NFKBIB; SMURF2; BMPR1B; TGFBR1; NFKBIA; ACVR1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

22kDa

References & Citations

Adams, M.D., (er) Ann. Rheum. Dis. (2008) In press

Shipping Conditions

Wet Ice

Protein Length

192

NCBI Gene Symbol

NKIRAS1

NCBI GB Accession Number

NKIRAS1

Host or Source

Rabbit

Protein Name

NF-kappa-B inhibitor-interacting Ras-like protein 1

Nucleotide Accession Number

NM_020345

Peptide Sequence

CETMEDVYMASVETDRGVKEQLHLYDTRGLQEGVELPKHYFSFADGFVLV

Price

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