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C2orf25 Antibody - middle region : Biotin (ARP55333_P050-Biotin)

Product Specifications

Gene Name

Methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria

Gene Aliases

CblD, C2orf25, CL25022

Gene ID

27249

Swiss Prot

Q9H3L0

Accession Number

NP_056517

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human C2orf25

Target

The function of C2orf25 remains unknown.Vitamin B12 (cobalamin) is an essential cofactor in several metabolic pathways. Intracellular conversion of cobalamin to adenosylcobalamin in mitochondria and to methylcobalamin in cytoplasm is necessary for homeostasis of methylmalonic acid and homocysteine. C2ORF25 encodes a protein involved in an early step of cobalamin metabolism (Coelho et al., 2008 [PubMed 18385497]) .[supplied by OMIM].

Partner Proteins

MMACHC

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

33kDa

References & Citations

Coelho, D., (2008) N. Engl. J. Med. 358 (14), 1454-1464

Shipping Conditions

Wet Ice

Protein Length

296

NCBI Gene Symbol

MMADHC

NCBI GB Accession Number

MMADHC

Host or Source

Rabbit

Protein Name

Methylmalonic aciduria and homocystinuria type D protein, mitochondrial

Nucleotide Accession Number

NM_015702

Peptide Sequence

RAEGYWADFIDPSSGLAFFGPYTNNTLFETDERYRHLGFSVDDLGCCKVI

Frequently Asked Questions

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