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HSPB8 Antibody - middle region : HRP (ARP55036_P050-HRP)

Selected Variant

ARP55036_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Heat shock 22kDa protein 8

Gene Aliases

H11, HMN2, CMT2L, DHMN2, E2IG1, HMN2A, HSP22

Gene ID

26353

Swiss Prot

Q9UJY1

Accession Number

NP_055180

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human HSPB8

Target

HSPB8 belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of HSPB8 protein is induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, HSPB8 appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in the encoding HSPB8 gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.

Partner Proteins

QRICH1; HSPB7; DUSP12; BAG3; ASB4; UBC; CIAPIN1; DSTN; HSPB6; HSPB3; SNCA; CRYAB; HSPB1; HSPB8; MAPK3; PRKCA; CSNK2A1; HSPB2

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

HSPB8 is supported by BioGPS gene expression data to be expressed in ACHN

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Goat: 77%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

21

Shipping Conditions

Wet Ice

Protein Length

196

NCBI Gene Symbol

HSPB8

NCBI GB Accession Number

HSPB8

Host or Source

Rabbit

Protein Name

Heat shock protein beta-8

Nucleotide Accession Number

NM_014365

Peptide Sequence

PEELMVKTKDGYVEVSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFA

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