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ITPK1 Antibody - N-terminal region : FITC (ARP54993_P050-FITC)

Selected Variant

ARP54993_P050-FITC

Size: 100 µL

Product Specifications

Gene Name

Inositol-tetrakisphosphate 1-kinase

Gene Aliases

ITRPK1

Gene ID

3705

Swiss Prot

Q13572

Accession Number

NP_055031

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human ITPK1

Target

ITPK1 is the kinase that can phosphorylate various inositol polyphosphate such as Ins (3,4,5,6) P4 or Ins (1,3,4) P3. It may also act as an isomerase that interconverts the inositol tetraphosphate isomers Ins (1,3,4,5) P4 and Ins (1,3,4,6) P4 in the presence of ADP and magnesium. It probably acts as the rate-limiting enzyme of the InsP6 pathway. ITPK1 modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.

Partner Proteins

UBC; TP53; NFKBIA; JUN; ITPK1; GPS1; COPS8; TRAF2

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

45kDa

References & Citations

Chamberlain, P.P., (2007) J. Biol. Chem. 282 (38), 28117-28125

Shipping Conditions

Wet Ice

Protein Length

414

NCBI Gene Symbol

ITPK1

NCBI GB Accession Number

ITPK1

Host or Source

Rabbit

Protein Name

Inositol-tetrakisphosphate 1-kinase

Nucleotide Accession Number

NM_014216

Peptide Sequence

MEVVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYI

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