ITPK1 Antibody - N-terminal region : Biotin (ARP54993_P050-Biotin)
Product Specifications
Gene Name
Inositol-tetrakisphosphate 1-kinase
Gene Aliases
ITRPK1
Gene ID
3705
Swiss Prot
Q13572
Accession Number
NP_055031
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human ITPK1
Target
ITPK1 is the kinase that can phosphorylate various inositol polyphosphate such as Ins (3,4,5,6) P4 or Ins (1,3,4) P3. It may also act as an isomerase that interconverts the inositol tetraphosphate isomers Ins (1,3,4,5) P4 and Ins (1,3,4,6) P4 in the presence of ADP and magnesium. It probably acts as the rate-limiting enzyme of the InsP6 pathway. ITPK1 modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.
Partner Proteins
UBC; TP53; NFKBIA; JUN; ITPK1; GPS1; COPS8; TRAF2
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
45kDa
References & Citations
Chamberlain, P.P., (2007) J. Biol. Chem. 282 (38), 28117-28125
Shipping Conditions
Wet Ice
Protein Length
414
NCBI Gene Symbol
ITPK1
NCBI GB Accession Number
ITPK1
Host or Source
Rabbit
Protein Name
Inositol-tetrakisphosphate 1-kinase
Nucleotide Accession Number
NM_014216
Peptide Sequence
MEVVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYI
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