IARS Antibody - middle region: Biotin (ARP54954_P050-Biotin)
Product Specifications
Gene Name
Isoleucyl-tRNA synthetase
Gene Aliases
IRS, IARS, ILRS, ILERS, GRIDHH, PRO0785
Gene ID
3376
Swiss Prot
P41252
Accession Number
NP_038203
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human IARS
Target
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Two alternatively spliced variants have been isolated that represent alternate 5' UTRs.
Partner Proteins
UBC; MDM2; SART3; AURKA; SUMO2; SUMO3; STAU1; LGR4; AIMP2; RPLP0; RPL38; RPL24; RPL23A; RPL18; RPL15; QARS; NMT1; MARS; MAP4; HNRNPA2B1; EPRS; DARS; AIMP1; HNRNPUL2; LARS; RPS27L; IGF2BP3; SYNCRIP; EEF1E1; FBXO6; EGFR; UBD; ITGA4; FN1; METTL18; gag; VCAM1
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/mL
Homology
Cow: 85%; Dog: 85%; Guinea Pig: 93%; Horse: 85%; Human: 100%; Mouse: 100%; Rabbit: 92%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
144kDa
Shipping Conditions
Wet Ice
Protein Length
1262
NCBI Gene Symbol
IARS
Protein Name
Isoleucine--tRNA ligase, cytoplasmic
Nucleotide Accession Number
NM_013417
Curated Selection
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