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RAPGEF1 Antibody - C-terminal region : HRP (ARP54753_P050-HRP)

Selected Variant

ARP54753_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Rap guanine nucleotide exchange factor (GEF) 1

Gene Aliases

C3G, GRF2

Gene ID

2889

Swiss Prot

Q13905

Accession Number

NP_005303

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human RAPGEF1

Target

RAPGEF1 is a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade protein may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation.This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.

Partner Proteins

UBC; MBIP; SLC20A1; ATXN1; RPS15; CRKL; CRK; CBL; GRB2; NEDD9; RHOQ; BCAR1; SHC1; RRAS2; HRAS; RAP1B; HCK; RAP1A

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

120kDa

References & Citations

Niclas, J., (2007) Exp. Cell Res. 313 (18), 3881-3891

Shipping Conditions

Wet Ice

Protein Length

1077

NCBI Gene Symbol

RAPGEF1

NCBI GB Accession Number

RAPGEF1

Host or Source

Rabbit

Protein Name

Rap guanine nucleotide exchange factor 1

Nucleotide Accession Number

NM_005312

Peptide Sequence

LWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIK

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