LYN Antibody - N-terminal region : Biotin (ARP54696_P050-Biotin)

LYN down regulates expression of stem cell growth factor receptor (KIT) .LYN acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation.LYN acts as a positive regulator of cell movement while negatively regulating adhesion to stromal cells by inhibiting the ICAM-1-binding activity of beta-2 integrins. LYN acts as the mediator that relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. Involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents.LYN induces SAPK by a MKK7- and MEKK1-dependent mechanism. The LYN -> MEKK1 -> MKK7 -> SAPK pathway is functional in the induction of apoptosis by genotoxic agents.

UBC; IKBKG; TRIM28; EGFR; RGS16; TNF; IL1B; ANGPT2; DKFZP434K028; CNOT10; TGDS; CBX6; FBXO28; ZNF423; RASSF8; FRS2; HBS1L; TUBB4A; SH2D3C; RIMS2; DDX21; KYNU; TNFSF12; PIK3R3; YEATS4; ZNF189; UGP2; HSP90B1; TADA2A; SLC12A4; RDX; PRKCB; SCIMP; LNP1; RNF180

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.