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KPNA4 Antibody - N-terminal region : Biotin (ARP54676_P050-Biotin)

Selected Variant

ARP54676_P050-Biotin

Size: 100 µL

Product Specifications

Gene Name

Karyopherin alpha 4 (importin alpha 3)

Gene Aliases

QIP1, SRP3, IPOA3

Gene ID

3840

Swiss Prot

O00629

Accession Number

NP_002259

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human KPNA4

Target

The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs) . Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. KPNA4 shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs) . Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Partner Proteins

HNRNPC; CYHR1; MAT2B; NUP50; PLAA; HSF1; UBC; LIN28A; rev; KPNA2; ACLY; SOX2; HDAC1; NACC1; CSNK2A1; AICDA; CBX5; APP; CUL3; DAXX; PARD3; ELAVL1; EXO1; CDKN1B; CUL4B; Ranbp2; Mki67; CTCF; MYC; TP53; H3F3A; RCC1; RAC1; RECQL; TGM2; KPNB1; CSE1L; ARRB2

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

KPNA4 is supported by BioGPS gene expression data to be expressed in HeLa, MCF7

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

58kDa

References & Citations

Yeung, P.L., (2008) J. Cell. Biochem. 103 (2), 456-470

Shipping Conditions

Wet Ice

Protein Length

521

NCBI Gene Symbol

KPNA4

NCBI GB Accession Number

KPNA4

Host or Source

Rabbit

Protein Name

Importin subunit alpha-4

Nucleotide Accession Number

NM_002268

Peptide Sequence

KNKRDEHLLKRRNVPHEDICEDSDIDGDYRVQNTSLEAIVQNASSDNQGI

Subunit

Alpha-4

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