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FKBP3 Antibody - C-terminal region : FITC (ARP54612_P050-FITC)

Product Specifications

Gene Name

FK506 binding protein 3, 25kDa

Gene Aliases

FKBP-3, FKBP25, PPIase, FKBP-25

Gene ID

2287

Swiss Prot

Q00688

Accession Number

NP_002004

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human FKBP3

Target

FKBP3 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP3 is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.

Partner Proteins

UBC; EDC4; IGF2BP3; SYNCRIP; SEC16A; EIF2B2; EIF2B3; DYNLL1; RFC4; YBX1; NMT1; KRT18; ILF2; HNRNPU; HNRNPA2B1; DDX1; ABCF1; MAP1S; C14orf166; DIMT1; NELFB; SRPK1; FBXO25; BARD1; MYH10; PACSIN3; LRRFIP1; TIMELESS; Nedd4; NEDD4L; CALM1; HDAC2; HDAC1; YY1; C

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

FKBP3 is supported by BioGPS gene expression data to be expressed in 721_B, HeLa, Jurkat, MCF7

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

25kDa

References & Citations

Meng, X., Biochem. Genet. 40 (9-10), 303-310 (2002)

Shipping Conditions

Wet Ice

Product Datasheet

Anti-FKBP3 (ARP54612_P050-FITC) antibody

Protein Length

224

NCBI Gene Symbol

FKBP3

NCBI GB Accession Number

FKBP3

Host or Source

Rabbit

Protein Name

Peptidyl-prolyl cis-trans isomerase FKBP3

Nucleotide Accession Number

NM_002013

Peptide Sequence

EALLTMSKGEKARLEIEPEWAYGKKGQPDAKIPPNAKLTFEVELVDID

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