GCLC Antibody - middle region: Biotin (ARP54577_P050-Biotin)
Product Specifications
Gene Name
Glutamate-cysteine ligase, catalytic subunit
Gene Aliases
GCL, GCS, GLCL, GLCLC
Gene ID
2729
Swiss Prot
P48506
Accession Number
NP_001489
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human GCLC
Target
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. GCLC is the catalytic subunit of 637 amino acids with a calculated molecular weight of 72.773 kDa. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia.
Partner Proteins
UBC; PPID; GCLM; CCL22; PAXIP1; ELAVL1
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
IHC, WB
Purification
Affinity Purified
Concentration
0.5 mg/mL
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 100%; Zebrafish: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
73kDa
Shipping Conditions
Wet Ice
Protein Length
637
NCBI Gene Symbol
GCLC
Protein Name
Glutamate--cysteine ligase catalytic subunit
Nucleotide Accession Number
NM_001498
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