IMPDH2 Antibody - N-terminal region : Biotin (ARP54365_P050-Biotin)

Product Specifications

Gene Name

IMP (inosine 5'-monophosphate) dehydrogenase 2

Gene Aliases

IMPD2, IMPDH-II

Gene ID

3615

Swiss Prot

P12268

Accession Number

NP_000875

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human IMPDH2

Target

IMPDH2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. It catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. IMPDH2 is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.

Partner Proteins

RSG1; APIP; HUWE1; UBC; IMPDH2; CDK2; RPA1; RPA3; RPA2; PRKAR2A; IMPDH1; EIF2S3; PARK2; MAPK10; SOX2; NPM1; PEX14; FN1; RPLP0P6; RPS6; RPL15; FOLR1; FBXO6; GRB2; UBQLN4; PIAS4; COPS5; COPS6; CUL3; YWHAZ; FBXO25; SIRT7; HDAC5; MME; SUMO4; AKT1; IKBKE; ATG5

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Sample Type

IMPDH2 is supported by BioGPS gene expression data to be expressed in 721_B

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.