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GSR Antibody - N-terminal region : HRP (ARP54344_P050-HRP)

Selected Variant

ARP54344_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Glutathione reductase

Gene Aliases

GR, GSRD, HEL-75, HEL-S-122m

Gene ID

2936

Swiss Prot

P00390

Accession Number

NP_000628

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human GSR

Target

GSR belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. It maintains high levels of reduced glutathione in the cytosol. Both glutathione and glutathione reductase are inducible by D3T, and that upregulation of GSH biosynthesis underlies D3T-mediated cytoprotection against ROS/RNS-elicited injury to human vascular smooth muscle cells.

Partner Proteins

SUMO1; CNDP2; GINS2; PROSC; AHSA1; NDRG1; DDX39A; NAMPT; KYNU; DDX39B; RPS6KA1; PEPD; MVD; LDHA; HSPD1; GBP2; EEF2; ADSS; C11orf49; UBC; FOLR1; ISG15; ELAVL1; SUMO4; PJA1; OCM; GSR

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Sample Type

GSR is supported by BioGPS gene expression data to be expressed in 721_B, HepG2

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 86%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 93%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

56kDa

References & Citations

Senturk, M., (2008) J Enzyme Inhib Med Chem 23 (1), 144-148

Shipping Conditions

Wet Ice

Protein Length

522

NCBI Gene Symbol

GSR

NCBI GB Accession Number

GSR

Host or Source

Rabbit

Protein Name

Glutathione reductase, mitochondrial

Nucleotide Accession Number

NM_000637

Peptide Sequence

PTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELP

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