GSR Antibody - N-terminal region : Biotin (ARP54344_P050-Biotin)
Product Specifications
Gene Name
Glutathione reductase
Gene Aliases
GR, GSRD, HEL-75, HEL-S-122m
Gene ID
2936
Swiss Prot
P00390
Accession Number
NP_000628
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human GSR
Target
GSR belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. It maintains high levels of reduced glutathione in the cytosol. Both glutathione and glutathione reductase are inducible by D3T, and that upregulation of GSH biosynthesis underlies D3T-mediated cytoprotection against ROS/RNS-elicited injury to human vascular smooth muscle cells.
Partner Proteins
SUMO1; CNDP2; GINS2; PROSC; AHSA1; NDRG1; DDX39A; NAMPT; KYNU; DDX39B; RPS6KA1; PEPD; MVD; LDHA; HSPD1; GBP2; EEF2; ADSS; C11orf49; UBC; FOLR1; ISG15; ELAVL1; SUMO4; PJA1; OCM; GSR
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
IHC, WB
Purification
Affinity Purified
Sample Type
GSR is supported by BioGPS gene expression data to be expressed in 721_B, HepG2
Concentration
0.5 mg/ml
Homology
Cow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 86%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 93%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
56kDa
References & Citations
Senturk, M., (2008) J Enzyme Inhib Med Chem 23 (1), 144-148
Shipping Conditions
Wet Ice
Protein Length
522
NCBI Gene Symbol
GSR
NCBI GB Accession Number
GSR
Host or Source
Rabbit
Protein Name
Glutathione reductase, mitochondrial
Nucleotide Accession Number
NM_000637
Peptide Sequence
PTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELP
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