GUCA1A Antibody - N-terminal region : Biotin (ARP54309_P050-Biotin)

GUCA1A (GCAP1) plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1) . GC1 is activated by decreasing Ca (2+) concentrations following photobleaching. The protein mediates the sensitivity of GC1 to Ca (2+) concentrations. GCAP1 promotes activity of GC1 at low Ca (2+) concentrations and inhibits GC1 activity at high Ca (2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3) ; a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca (2+) concentrations; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.