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LIG1 Antibody - middle region : Biotin (ARP54307_P050-Biotin)

Selected Variant

ARP54307_P050-Biotin

Size: 100 µL

Product Specifications

Gene Name

DNA ligase 1

Gene ID

3978

Swiss Prot

P18858

Accession Number

NP_000225

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human LIG1

Target

This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants.

Partner Proteins

PCNA; UBC; PRMT3; SUMO2; RGS2; TUBB3; MRE11A; INPP1; CSNK2A1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

LIG1 is supported by BioGPS gene expression data to be expressed in HepG2

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 100%; Goat: 79%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 93%; Zebrafish: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

102kDa

References & Citations

Liang, L., (2008) Nucleic Acids Res. 36 (10), 3297-3310

Shipping Conditions

Wet Ice

Protein Length

919

NCBI Gene Symbol

LIG1

NCBI GB Accession Number

LIG1

Host or Source

Rabbit

Protein Name

DNA ligase 1

Nucleotide Accession Number

NM_000234

Peptide Sequence

ALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSVTSFILDTEAVAWDR

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