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GSN Antibody - C-terminal region : Biotin (ARP54299_P050-Biotin)

Product Specifications

Gene Name

Gelsolin

Gene Aliases

ADF, AGEL

Gene ID

2934

Swiss Prot

P06396

Accession Number

NP_000168

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human GSN

Target

GSN binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. It is a calcium-regulated protein, which functions in both assembly and disassembly of actin filaments. Defects in the gene encoding GSN are a cause of familial amyloidosis Finnish type (FAF) .The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF) . Multiple transcript variants encoding several different isoforms have been found for this gene.

Partner Proteins

ITCH; CFLAR; TP53; UBC; CASP3; UBD; FN1; MPG; ESR1; ALB; SDHB; ACTA1; MDM2; UBE2Q2; FBXO25; ARRB2; ARRB1; AR; PSMD4; TNIK; CLIC5; TOM1L1; ACTN4; VDAC1; BCAR1; PXN; LIMK2; VASP; PIK3CG; PTK2B; FHIT; VCL; CSK; APP; ACTB; ACTG1; PLCG1; SRC; PTPN12; PTK2; PIK

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB, IHC

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 100%; Sheep: 100%; Zebrafish: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

83kDa

References & Citations

Shokouhi, G. Nephrol. Dial. Transplant. 23 (3), 1071 (2008)

Shipping Conditions

Wet Ice

Protein Length

782

NCBI Gene Symbol

GSN

NCBI GB Accession Number

GSN

Host or Source

Rabbit

Protein Name

Gelsolin

Nucleotide Accession Number

NM_000177

Peptide Sequence

KPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSN

Frequently Asked Questions

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