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GLDC Antibody : HRP (ARP54297_P050-HRP)

Selected Variant

ARP54297_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Glycine dehydrogenase (decarboxylating)

Gene Aliases

GCE, GCSP, HYGN1

Gene ID

2731

Swiss Prot

P23378

Accession Number

NP_000161

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the following sequence LENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLDMANASLLDEGT

Target

Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase) . The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH) .

Partner Proteins

SUZ12; UBC; CUL2; TNFAIP3; TLR10; GLDC

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

IHC

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

113 kDa

Shipping Conditions

Wet Ice

Protein Length

1020

NCBI Gene Symbol

GLDC

NCBI GB Accession Number

GLDC

Host or Source

Rabbit

Protein Name

Glycine dehydrogenase [decarboxylating], mitochondrial

Nucleotide Accession Number

NM_000170

Peptide Sequence

LENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLDMANASLLDEGT

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