ULK1 Antibody - N-terminal region : HRP (ARP54261_P050-HRP)

ULK1 is a serine/threonine-protein kinase involved in autophagy in response to starvation. It acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. It is activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. It may phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences and plays a role early in neuronal differentiation and is required for granule cell axon formation.

SESN2; SQSTM1; ATG16L1; EXOC8; EXOC2; BECN1; RALB; AMBRA1; ULK1; UBC; TRAF6; MBP; ATG13; MAP1LC3C; MAP1LC3A; MAP1LC3B; GABARAPL1; GABARAPL2; GABARAP; MLST8; RPTOR; MTOR; PPP1CA; ATG4B; CDC37; G3BP1; RB1CC1; USP10; PRKAG1; PRKAB2; PRKAA2; PRKAA1; SYNGAP1

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.